Can I use regular speaker wire for my powered sub-woofer with the appropriate connectors?

i would not recomend that I am an electronic tech in commercial electronics but I am also very familiar with home audio. Because you have a powered sub it has its own amp, speaker wire is unshielded and is more likely to pic up noise on the line and a very small bloop on the line going to your sub will be amplified and will not sound good coming through your sub. If your looking to save some money just find some old RCA plugs (composite audio video) and just use a single plug from your amp to reciever. Composite RCA plugs are the same thing you would buy at best buy, only diff is the colors red white yellow where a sub cable is ussualy green or other uncommon colors. hope that helps

No. You have 2 kinds of signals behind your gear: * Speaker Level - This carries WATTS of power to drive motors (speakers are motors). You use 2-conductor speaker wire for this. * Line Level - These are very weak signals. You have to use shielded RCA cables for these signals. Your subwoofer takes a feed from an RCA jack output on your receiver to an RCA jack input on the sub. So the proper wire to use....(que Captain Obvious): An RCA cable. You do not need an expensive cable for this, but it should be long. Try www.monoprice.com or Amazon for inexpensive cables.