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How Rare is Duane's Syndrome?

If two parents both have down syndrome, will their children have down syndrome?

  • I am wondering if two people with down syndrome have a child, will down syndrome be present in their children, will it be a just a possibility, or will their children not have down syndrome?

  • Answer:

    Considering the statement below, if 2 people with Down's were even able to conceive and have a viable birth, it would be very likely it would also have the disorder, as down's is caused by an extra chromosome, and two poorly mutated chromosomes put together would probably not be "normal". i don't understand genetics especially well, but I don't think they could have a child without the disorder. "There is infertility among both males and females with Down syndrome; males are usually unable to father children, while females demonstrate significantly lower rates of conception relative to unaffected individuals. Women with DS are less fertile and often have difficulties with miscarriage, premature birth, and difficult labor. Without preimplantation genetic diagnosis, approximately half of the offspring of someone with Down syndrome also have the syndrome themselves. Men with DS are almost uniformly infertile, exhibiting defects in spermatogenesis. There have been only three recorded instances of males with Down syndrome fathering children."

Tim at Yahoo! Answers Visit the source

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the typical human has 23 pairs of chromosomes (46 total) someone with DS has 47... Someone has claimed that new research shows that it is unlikely that the offspring would be effected, but I had located a study that said most were when the mother was affected. If I remember correctly, 1/3 had DS and another 1/3 had other severe disabilities or were not viable. There is only a couple recorded cases of a male fathering a child, it is believed that most males are infertile. http://www.ndss.org/index.php?option=com_content&view=article&id=134%3Asexuality&catid=50%3Atransition-a-adulthood&Itemid=141&limitstart=1 At least half of all women with Down syndrome do ovulate and are fertile. Between 35 and 50 percent of children born to mothers with Down syndrome are likely to have trisomy 21 or other developmental disabilities. http://ds-health.com/issues.htm%5C even with hair color--there is a 50% chance of a gene from a single parent being passed on..to make it simple--if the mother has a red gene and a black gene..there is a 50% chance the child will be red and 50% green the only time 1 in 4 comes into play is when it is recessive and both parents have the recessive gene...blue eyes are recessive so if mom and dad both have a blue/brown chromosome..there is a 1 in 4 chance the baby will have blue eyes DS is not a recessive trait except in one rare variation of DS

jmitw

They are more likely to have it but not certain.

I'm awesome

Not necesserily, when an egg is fertalised the stem cells that form start to form the embryo in the mothers womb the stem cells have 4 posible outcomes, for example hair colour is determined by a certain chromosome from each parent has 2 colour outcomes from each parent making 4 overall, its the same here, the outcomes will be downs and neurotypical, as both parents have downs theres a 50:50 chance of downs in each baby they get, the chance goes down to 1:4 if one has it.

wikipeter.

I'm not sure, but I think I've read that they can't have children. I was right, at last... http://en.wikipedia.org/wiki/Down_syndrome

Pino dei Palazzi

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