Gene mapping question.

Question about how the location of Sry gene affects sexual development?

• Okay, so I'm doing some genetics homework and have a quick question to help me answer some of these. So, I know that the Sry gene on the Y chromosome is the key for male sexual development and that individuals with 46, XX disorder are male if crossing over during meiosis resulted in the Sry gene getting recombined to one of the X chromosomes. My question is, if the Sry was, for some reason, located on an autosome, would the individual still be male? I have several questions asking me to determine the sex of someone with varying numbers of X chromosomes with the Sry gene located on an autosome.

• Answer:

  Some but not all individuals with the syndrome have SRY, the gene normally found on the Y chromosome that makes for malesness. This is often due to an abnormal interchange between the Y chromosome and the X chromosome, resulting in presence of the SRY gene on the X chromosome and infertility. It may also be due to translocation of SRY to an autosome (a non-sex chromosome). The X/autosome translocation can occur de novo (be new) or be inherited from a parent. ---- http://www.medterms.com/script/main/art.asp?articlekey=25059 Men 46 XX, translocation of a piece of Y conatining SRY on an autosome or X -- http://www.gfmer.ch/Endo/Course2003/Gametogenesis.htm