Why do sharks have high urea concentrations?

What happens to the intracellular and extracellular concentrations of urea it the kidneys stopped functioning?

  • Answer:

    Intracellular urea concentrations tend to increase following renal failure, although the likelihood of elevated extracellular urea (measured as BUN, or blood urea nitrogen) is far greater than elevated intracellular urea. Consequently BUN is commonly used to detect kidney dysfunction.

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