How Rare is Duane's Syndrome?

My brother has morquio syndrome. what is the chance of his kids to have morquios syndrome?

• i have two brothers that have morquio syndrome. one of them was wondering if he gets marry, what will the chance of his kids to have morquios syndrome? note that my father's uncle (my father's mother brother) has two kids that have morquio syndrome which are a boy and a girl. so is that consider a family history of morquio syndrome?

• Answer:

  I actually 'Googled' this subject and maybe you ought to do the same. I found the following on a website I found: How is the disease inherited ? We all have genes inherited from our parents which control whether we are tall, short, fair, etc. Some genes we inherit are 'recessive', that is to say we carry the gene but it does not have any effect on our development. Morquio disease is caused by a recessive gene. If an adult carrying the abnormal gene marries another carrier there will be a one in four chance with every pregnancy that the child will inherit the defective gene from each parent and will suffer the disease. There is a two in three chance that unaffected brothers and sisters of Morquio sufferers will be carriers. They can be reassured however that, as the disease is so rare, the chance of having a partner who is another carrier is very slight provided their partner is not a cousin or other close family member.