What's the difference between a disease and a disorder?

Whats the difference between an antibody mediated disease and an organism mediated disease?

• Im confused on how they are different I guess. Are any of those similar to a cell mediated disease or am I thinking of something completely different?

• Answer:

  The present invention describes diagnosis and treatment of antibody-mediated inflammatory auto-immune diseases. The biochemical mechanisms underlying such disorders are described as characteristic molecular markers and antibody-mediated ligand-receptor interactions. Specifically, the activation of T-cells by disease specific IgG binding to the IGF-1 receptor is shown to underlie thyroid associated ophthalmopathy associated with Graves' disease and rheumatoid arthritis. Diagnostics for detection of disease are provided, as are therapeutics based on the determination of the mechanisms underlying a particular pathology. An organism mediated disease works thus: Anti-RBC antibodies are formed against normal (primary IMHA) or altered (secondary IMHA) RBC membrane antigens. Infectious organisms, exposure of previously unexposed antigens, or adsorption of pre-formed antigen-antibody complexes to the RBC membrane can alter RBC membrane antigens. Antibodies can be warm type (reactive at body temperature, usually IgG) or cold type (reactive at subnormal body temperature, usually IgM).