What is the feedback mechanism of insulin and the concentration of glucose in the blood?

What effect does insulin have on the concentration of blood glucose?

  • Answer:

    Insulin response comes about from receptor tyrosine kinase. When insulin binds to the alpha portion of the RTK, the receptors dimerize. This results to its beta intracellular portion to autophosphorylate. This creates a binding site for IRS-1. When IRS-1 is activated, it recruits glut-4 receptors, allowing glucose to be taken in from the blood (therefore blood conc. will fall under insulin)

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