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If bacteria communicate with one another using chemical signal molecules, what is the best way to visualize this process by analogizing it to some activity that occurs in the visual world that humans inhabit and can readily see in the 'real" world around them.

  • I currently analogize the process by imagining bacterial communication as humans using a cell phoney. But that may be just the product of an overactive imaginaton. Background: Note that some honey has antibacterial properties that inhibit quorum sensing in bacteria. Could there also be an associated process whereby the honey enhances the quorum sensing in human cells such that they are able to better communicate and thereby "clean" a wound by enhancing the bodies ability to cast off foreign and unwanted invaders, as is evidenced by Manuka honeys ability to cause the body to cast out dead tissue and all known antibiotic resistant bacteria, as Manuka honey has been proven to "kill". In other words, is the body actually doing the work by digesting something in Manuka honey? Perhaps we are studying the wrong thing and should be studying how the human body is changed by digesting Manuka honey through a wound. Dr. Molan, a biochemist i in New Zealand has said is something that the body actually does.  He also says an open wound "digests" manuka honey and it is used to as an energy source perhaps like glycogen is used except here it is used as an energy source to help rebuild human tissue. Here is part one of an eight video series of videos of Dr. Molan on Manuka honey: I have observed the healing  process of a wound repairig and rebuilding tissue from a large wound and can actually say that I believe it is observable - that is one can see that  the honey is being digested by close observation. Could honey actually be changing the biology of the human cells themselves, and not just killing the cells outright? http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323871/ So understanding quorum sensing is essential to understanding how bacteria are cast off, killed or otherwise rendered harmless when Manuka honey is used on wounds. I am skeptical of claims that eating the honey is helpful for its ability to enhance healing when digested because exposure to stomach acids may render it useless. Nevertheless, some say it is useful for acid reflux. My observations are anecdotal but I don't find this to be true. All these observations are anecdotal. But I have an inquiring, or enquiring, mind and want to understand how the process works and understanding quorum sensing is important for this lay person not schooled in medicine to understand what it is in honey that causes the biological process of healing in a leg wound to occur in what appears to be a magical and mysterious way, unlike any other healing process that I have experienced in my short fifty six hears of observing wounds healing. Manuka honey allows one to see an open wound because all dead tissue is cast off. Thus there is no scab fomation causing this  process to be observable so  one can 'see" the body actually rebuilding human tissue because the wound is left open and observable. By close observation I can see the process and there appears to be a whole city  of workers carrying about their duties in rebuilding lost tissue. One can see the scaffolding built, and covered over, then the workers must thereafter enter into the structure and go about building the protected areas inside. Or so it seems in my overactive imagination.  I would analogize my imaginative process at work here by reference to Henry David Thoreau's passage in Walden whereby two ant beds are at war and he cannily analogizes destructive human activity such as war by closely observing the ants battling it out.  However I believe that Manuka honey alters the biology of the human body and we need to understand that process if we are to unlock the secrets which bee colonies use to protect their food source from bacteria and in turn, what it is in Manuka honey that alters the human cells that rebuild and protect the body from invaders. If we can understand the biological process at play, we may make greater strides in learning how to conquer antibiotic resistant bacteria. We need to study the bees more to learn their secrets in producing Manuka honey (and also the honey that one company is attempting to patent, a horrendous crime in my opinion) . I am aware that methylglyoxal  http://www.ncbi.nlm.nih.gov/pubmed/21520131 is being studied heavily as it is said by some to be the active ingredient in Manuka honey. I believe that research is going to ultimately result in a dead end. There is more at play here than the chemical process. There is also a not understood biological process but I believe there are not just bees that produce colonies of workers each performing a special task. Human cells are probably organized in the same way. Perhaps something in that honey is giving human cells instructions in how to cast off or kill bacteria. Within our body the cells are possibly societal in the same way that bees have a social structure as do the ants that Thoreau observed, the black ants battling the red ants as Thoreau observed in "Walden".  http://grammar.about.com/od/classicessays/a/battlethoreau.htm Would it not be too preposterous to believe that the bees produce something that contains instructions that human cells recognize and thereby are able to understand and carry out and thereby become better at fighting bacteria. The ants that Thoreau observed might have social structures similar to bees, as well as human cells within our body. Surely it is not too outlandish to think that at some biological level beyond our current level of understanding, the evolutionary structure of cells is similar in that all of us began by the first stirrings of life upon the planet. Life began as single cell organisms. And perhaps we are not too much different than bees as wells as ants in that our biological processes, i.e. cellular societies  are capable of conversing with each other.  Thus the question about the cell phone and my question making the analogy. Bees communicate with each other/. We know their dances and have learned to understand the dance of the worker bee giving directions to the nearest pollen source to a whole hive of bees. . Perhaps we too have cells that dance inside of us just like the bee societies humans have come to understand and have learned part of their "language" If we ever understand that language and how it works, we might be able to cure every scourge upon the earth that operates against us at the cellular level, such as cancer.Manuka honey is currently being studied at the Mayo clinic as a possible treatment for or cure for some cancers.. A link to one one those studies is here:  http://www.mayo.edu/research/clinical-trials/CTS-00104997 There are many more. So dance on and learn the dances. It might take us to places beyond our wildest imagination. PS I've got to go. My cell phone is calling.

  • Answer:

    Imagine that you have a room of mouse traps set up so that if any three of the mouse traps are triggered then the lights turn on. If a mouse trap has been triggered it will automatically reset itself after one minute. Now start dropping in ping-pong balls into the room, mostly at random. The faster you drop ping-pong balls into the room the more likely you are to set off three mousetraps at once. The mousetraps are the chemical receptors and the ping pong balls are the molecules from other bacteria.

Tony Miller at Quora Visit the source

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I would give you the analogy of a twitter network that has a limit of one word and not the 140 characters we know and hate. Those words are also limited to a small dictionary.

Malcolm Sargeant

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