What makes fibromyalgia symptoms come and go?

From a sufferer stand point I'm seeing a lot of the latest research is correlating with the relationship between highly verbal females and right brain issues. I'm not sure I understand the multisensitivity syndrome. But I do feel it's part of the muscle chemistry and electrical system if I can use that as an analogy. I suffer from alot of miss firing signals in my muscles:Twitching and shooting electrical type pain. I suffer from the bruise like trigger point pain. Some doctor who specialize in FMS have in the past used the common areas of neck, hip and thigh pain as markers for diagnoses. This has changed over the past few years. The scope is broader  but could this merely  convolute any significant findings? The same type of hardcore diagnoses are used after taking the drugs Lyrica and Cymbalta. They may alter sensations in the short term but have no effect on long term prognosis. People who have some success with these drugs may fall into 2 catagories,some may actually have relief, others may be so desparate for relief it may act as a placebo. Side effects out weigh benefits in both groups. Needless to say there are very few firm answers because of it's  broader and broader inclusivity. IMO by the time we have any break through we may have many more names for all these symptom sets. When I was first diagnosed it was likened to a short circuit of the body's electrical system. It still seems that way but why can't we reset the system to be normal or even stronger? Now I  call it ridiculously Oppressive.

You're asking for an etiology -- the process by which an illness does what it does. And the answer is we don't know for sure yet. There have been a few theories which have some substantial research backing -- my own favorite is that it's a disruption of the hypothalamus/pituitary/adrenal axis. This has unfortunately been picked up by a lot of quacks because they can justify practically anything they want to sell you by claiming it can make the HPA axis settle down, so be careful whom you believe in reading the details; but the fact that the HPA axis is involved does seem to be real, from the studies I've read.

There are quite a few theories in the medical literature at http://pubmed.Gov about what pathways are involved in FM. I support the "central sensitization syndrome" school that ranks FM among many similarly triggered syndromes involving pain of some kind. When multi-sensory sensitivity is involved --to odors, lights, sounds, touch, etc--the primary mechanism is increased endogenous production of CO via heme oxygenase,HO, the universal stress enzyme that degrades heme into CO, iron and biliverdin. This CO competes with oxygen in binding to myoglobin in muscles as well as to cytochromes in mitochondria, impairing oxidative metabolism and causing symptoms of both FM and chronic fatigue syndrome. The multi-sensory sensitivity results from CO poisoning because CO acts as a gaseous neurotransmitter that modulates the nerve action firing potential of sensory nerves. Too much CO--from acute external exposure--can leave you literally senseless but post exposure, survivors may become hypersensitive to even the small levels of CO that our bodies make 24/7 from normal heme catabolism. Sensory stressors trigger reactions not because light and sound are toxic but because they trigger HO to degrade more heme which makes more CO. And it is to CO that people with multi-sensory sensitivity are reacting. Their higher than normal body burden of CO can be measured easily in their exhaled breath using any professional CO detector.