Whats the usage of measuring human body cell voltage?
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experimenters measure the cell voltage using some techniques such as voltage,current,patch clamp.why do they do this? whats the usage of this measuring?
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Answer:
Every cell has a potential difference (voltage) across its membrane, due to the relative distribution of positively charged ions across that membrane--about a 10-fold higher concentration of sodium (Na+) outside the cell compared with the inside, and about a 35-fold higher concentration of potassium (K+) inside the cell compared with the outside. This difference is maintained by energy-using pumps which pump sodium out while pumping potassium in. In fact, in most cells this pumping is the #1 consumer of energy in every cell. Normally, the inside of the cell has fewer + charges than the outdside (because the pumps pump out 3 Na+'s for every 2 K+'s they pump in), so we say that the inside is negatively charged relative to the outside--i.e. because there is a difference in charge across the membrane the cell is electrically POLARIZED. Changes in the polarization state [e.g. HYPERpolarization--inside becoming even more negative with respect to the outside or DEpolarization--where a bunch of + charges get in] and the specific movements of particular ions are associated with changes in cell function can be measured using the methods you mentioned. For example, rapid and transient changes in polarization state (of Na+ and K+) are the basis for nerve signalling. There are other ions whose movements can be tracked--e.g. Ca++, Cl-, but Na and K are the two main ones. It does not take very many individual ion molecules to cause significant changes in membrane polarization, and these changes are very transient--e.g. a change of less than 100 millionths of the total number of ions rushing in then being pumped back out in just a few thousandths of a second, but the changes in cell function triggered by these rapid changes can be profound. Measurements of voltage yield information about the state of cell polarization, and the patch clamping methods you mention yield specific information about which particular ions are flowing across the membrane and how large a current they are carrying.
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Other answers
The body has two wiring systems that carry voltage to each organ. ... It is difficult to use a voltmeter to measure the organ voltage because voltage ... Cells in the adult human are designed to run at -20 to -25 millivolts and to heal at -50 millivolts.
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