How to calculate the amount of ATP if there is a mutant strain of complex 3 and can't pump protons out of the matrix.?
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If there is a mutant strain on complex 3. How do you calculate the number of ATP produced (complete breakdown of glucose). Starting from Glycolysis to ATP synthase.
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Answer:
A pair of transportated electrons produces the enough energy to translocate 10 protons, enough to reduce only half a O2 molecule. Complex I: 4H+ Complex II: no protons Complex III: 4H+ Complex IV: 2H+ The complex III receives electrons from complex I and II through ubiquinone and gets rid of them through cit c, which go to complex 4. As you can see, the complex III can be seen as an electron receiver/donator central. A mutant strain in it wouldn't allow the electron flow, thus stopping protons translocation. No ATPs. Obviously, if there are living people with no complex 3, the body responds and produces a different route to produce ATPs, but these are very little. Only the ones obtained from glycolysis (2), and the krebs cycle (2), and as I mentioned before some electron carriers get saturated as not all electrons can be put into oxygen at the electron transport chain therefore giving an even lower amount. "The observed decline in the activities of complex-I, -IV, and -V was not physiologically relevant and did not contribute to compromised respiration and ATP synthesis in infected myocardium. Instead, complex III activity was decreased above the threshold level and contributed to respiratory-chain inefficiency and the resulting decline in mitochondrial ATP synthesis in infected myocardium." https://s.yimg.com/hd/answers/i/516490d9c4324662b11fa47d7629fc80_A.png?a=answers&mr=0&x=1402618518&s=e8ff2e4c6b9eb30751565964866af685
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