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How does the process work by which certain genetic information from each parent are combined into the unique genetic information of a child?

  • Certain traits from each parent are passed to a child while others are not. One child inherits a different combination of traits than its sibling. How does the selection and recombination of genetic information work on a chromosome/DNA level in sexual reproduction? Is this process completely random or is it biased in some way to ensure the selection of "better" traits?

  • Answer:

    As far as we know, it is generally random. Favorable and unfavorable traits have equal probabilities of being passed on from one parent to one offspring, but unfavorable traits make it less likely that the parent has offspring (or perhaps less likely for the offspring to reproduce, or some other similar variant). As Jacobo says in the comments, there are some processes, such as meiotic drive, that make it more likely for one trait to be passed on to offspring than another, but that may happen to favorable as well as unfavorable traits. Humans have 46 chromosomes, of which 23 (including the Y chromosome in men and one X chromosome in women) come from the sperm (i.e., the father) and 23 (including an X chromosome for both sexes) come from the egg (i.e., the mother). In addition, we inherit mitochondrial DNA from our mothers. Eggs and sperm thus have only 23 chromosomes, but they derive from normal human cells with 46 chromosomes, which form 23 pairs, each consisting of one chromosome from the mother and one from the father. The chromosome number is halved in a process called meiosis, which produces four 23-chromosome from one 46-chromosome one. During this process, all chromosomes are duplicated, the members of each chromosome pair align with each other, then split into two daughter cells that both contain 23 doubled chromosomes. Last, the two daughter cells split into two cells, each containing 23 non-doubled chromosomes. However, during this process a phenomenon named crossing over happens: within one chromosome pair, pieces of chromosomes are exchanged between different chromosomes. This means that the chromosomes we get are almost never exactly those our parents got from their grandparents, but rather mosaics that derive from both of our parents' parents.

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Other answers

Chromosomes segregate randomly, however genes/traits on the same chromosome do not necessarily.  If genes are located near each other, they are said to be linked.  Linked genes will more often get passed on together because they are less likely to be separated by crossing over in meiosis.  Thus you can have pairs of traits caused by different genes but that do not segregate randomly. This process that controls this however is almost completely random. There are recombination hot spots (where recombination occurs more frequently than elsewhere in the genome) but it is otherwise random.  The only way there is selection against bad traits is when some defect prevents completion of pregnancy, but this only occurs after fertilization, not during in the production of gametes/sex cells.

Justin Smith

It is not, I think, a completely random process. There is for example the "Meiotic drive" process that provokes a subversion of meiosis so that particular genes are preferentially transmitted to the progeny creating a preferential segregation of small regions of the genome. In humans, some rate genetic defects follow this mechanism of transmission. For example, males with achondroplasia will have a higher proportion of gametes (spermatozoids) carrying the altered gene responsable for this disease.

Jacobo Mendioroz Peña

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