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When is a single base substitution mutation least likely to be deleterious?

Why is a frameshift mutation more harmful than a base-substitution mutation

  • Answer:

    Frameshift mutation is more harmful than base-substitution mutation because the outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein. This alteration occurs during translation because ribosomes read the mRNA strand in terms of codons, or groups of three nucleotides.

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Frameshift mutation is more harmful than base-substitution mutation because the outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein. This alteration occurs during translation because ribosomes read the mRNA strand in terms of codons, or groups of three nucleotides.

Denise Charles

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