I'm looking for the most comfortable, hassle-free approach to wearing contact lenses.

I have daily throwaway lenses and I would never, ever go back to two week or monthly or whatever. Keeping in mind, however, that I have over time developed a pretty severe reaction to the protein that gets on lenses, and cleaning them was insufficient for me. However, the fact remains - new lenses are clean lenses and clean lenses are comfortable lenses.

I have very sensitive/fussy eyes and tried a bunch of different types of contacts before settling on daily wears. I wear them 1-2 times and throw them out. Problem solved. I wouldn't recommend anything that you wear overnight or for several days at a time for someone who has sensitive eyes. And that's what my eye doctor said as well.

I wouldn't call Clear Care hassle-free, which is what the OP requested. If you want hassle-free, go for daily-wear and throw them out, or get extended wear lenses abut wear them daily for a month at a time. Don't sleep in them. Soak them in a multi-purpose solution nightly that will take off the protein deposits. No special case required, no timing needed. I was told by the cashier at the optical place where I shop that I was 'eligible' to buy the Acuvue 2s because I'd been buying them all along but that all of their new patients were getting the Oasys. I said "what's the difference?" and she said "nothing but the price, really."

I've worn contacts for 10 years or so and I've never found a solution that makes my eyes feel cleaner and healthier than Clear Care does. I've had 30-day contacts feel clean well into six weeks (shh, don't tell my eye doc), whereas a new pair of contacts would always feel gunky after a few days of using SoloCare. I too really hate removing my lenses as well. What I found to be most convenient and cheap was to wear Acuvue 2s full-time for a week. Wearing Focus Day And Nights for a month and soaking every 10 days or so is a close second, but those lenses are more expensive where I am and tend to dry out somewhat easily. Acuvue Oasys on a weekly schedule are probably the best way to go in therms of comfort and visual clarity, but they're 3x the price of Acuvue 2 so I was willing to accept the tradeoff and stick with the slightly-less wonderful Acuvue 2s.

Clear care is awesome. Just don't get it in your eyes! (I wish I could wear soft contacts; I had a severe allergic reaction to them after wearing them for a year and no longer can wear them. I wore RGP lenses for three years, but I just got tired of the hassle with them and the pain and how uncomfortable they were). Good luck!

I'm currently using Acuvue 2, you leave them in full-time for 2 weeks then replace. Absolutely brilliant, I used to use dailies, but the hassle factor of fiddling with your eyes, falling asleep in them, along with the amount of waste (60 empty plastic containers a month vs. 4) With these lenses my eyesight is definitely sharper then the same precription in daily disposables, I even tried wearing a daily in one eye and a biweekly in the other and the difference was very notable. As an added benefit the biweekly ones work out cheaper, win/win.

I really like the Clear Care too. I am definitely switching when I finish this bottle of regular no-rub solution.

It sounds like you haven't tried 1-day disposables. They completely address the hassle factor. And I find them very comfortable -- even more so now that I'm wearing Acuvue "Moist".

Chiming in to recommend the Focus Night and Days. My wear schedule: In on the 1st, out for one night to soak around the 15th, throw away on the 31st (and sleep with no contacts that night, so I basically go two weeks at a time not thinking about my eyes). They're not just comfy, they're forgettable. My eyes don't feel a thing on them. Total time spent = maybe 10 minutes/month. I also am in love with the Aquify solution.